Objective: Type VIIcollagen, the major component of anchoring fibrils, has been suggested to be involved with tumor cell invasion in a laminin-5-dependent manner in skin squamous cell carcinoma. However, the significance of type VII collagen expression in esophageal squamous cell carcinoma (ESCC) has been unknown to date. Therefore, we examined the expression of type VIIcollagen in ESCC, and confirmed the association between type VIIcollagen expression and clinicopathologic characteristics.
Methods: We immunohistochemically examined the expression of type VII collagen and laminin-5 gamma2 chain in surgical specimens of primary tumors in 109 patients with ESCC.
Results: Positive cytoplasmic expression of type VII collagen was detected in 35%. Significant correlation between the expression of type VII collagen and laminin-5 gamma2 chain expression was observed. In the type VII collagen-negative group, the 5-year survival rate was significantly better than in the positive group. Multivariate analysis indicated that the positive expression of type VII collagen was an independent prognostic factor.
Conclusions: The expression of type VII collagen was closely related to poor prognosis. Type VII collagen cytoplasmic expression could be a useful marker for evaluating the tumor cell properties, including prognosis, in patients with ESCC.