Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the treatment of depression: a new strategy to shorten the latency of antidepressant medication?

Mol Psychiatry. 2007 Aug;12(8):704-6. doi: 10.1038/sj.mp.4002005.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Pharmaceutic / administration & dosage*
  • Amino Acids / administration & dosage
  • Animals
  • Antidepressive Agents, Tricyclic / administration & dosage*
  • Bridged Bicyclo Compounds, Heterocyclic / administration & dosage
  • Depressive Disorder / drug therapy
  • Disease Models, Animal
  • Drug Interactions
  • Drug Therapy, Combination
  • Excitatory Amino Acid Agents / administration & dosage*
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • Hippocampus / metabolism
  • Imipramine / administration & dosage*
  • In Vitro Techniques
  • Mice
  • Neurons / drug effects
  • Rats
  • Rats, Inbred Strains
  • Receptor Cross-Talk / drug effects
  • Receptors, Metabotropic Glutamate / drug effects*
  • Receptors, Metabotropic Glutamate / metabolism
  • Time Factors
  • Xanthenes / administration & dosage

Substances

  • Adjuvants, Pharmaceutic
  • Amino Acids
  • Antidepressive Agents, Tricyclic
  • Bridged Bicyclo Compounds, Heterocyclic
  • Excitatory Amino Acid Agents
  • LY 341495
  • LY 379268
  • Receptors, Metabotropic Glutamate
  • Xanthenes
  • metabotropic glutamate receptor 2
  • metabotropic glutamate receptor 3
  • Imipramine