Abstract
The first member of a novel class of chemoselective reagents, glycosyl methanedithiosulfonates, has been synthesized, identified and employed in the first examples of chemical, site-selective construction of a trisulfide-modified protein with complete conversion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanesulfonates / chemical synthesis
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Alkanesulfonates / chemistry*
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Crystallography, X-Ray
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Glycoproteins / chemical synthesis*
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Glycoproteins / chemistry
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Protein Conformation
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Sulfides / chemical synthesis*
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Sulfides / chemistry
Substances
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Alkanesulfonates
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Glycoproteins
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Sulfides