The clinical course of a patient with pyrosis and intractable hiccups is presented. Hiccups persisted six years after an effective fundoplication had cured pyrosis, and the patient was eventually treated with baclofen. Esophageal function during and after hiccups was studied in detail by means of esophageal manometry and 24-hour-pH monitoring. The relationship between hiccups and gastro-esophageal reflux is discussed.