Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome

Daniela Romualdi; Giuseppe Campagna; Luigi Selvaggi Jr; Rosa Cento; Caterina Proto; Antonio Lanzone; Maurizio Guido

doi:10.1016/j.fertnstert.2007.05.004

Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome

Fertil Steril. 2008 May;89(5):1273-1276. doi: 10.1016/j.fertnstert.2007.05.004. Epub 2007 Jul 20.

Authors

Daniela Romualdi¹, Giuseppe Campagna¹, Luigi Selvaggi Jr¹, Rosa Cento², Caterina Proto², Antonio Lanzone³, Maurizio Guido⁴

Affiliations

¹ Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
² "Oasi" Institute for Research, Troina, Italy.
³ Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy; "Oasi" Institute for Research, Troina, Italy.
⁴ Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: [email protected].

PMID: 17658527
DOI: 10.1016/j.fertnstert.2007.05.004

Abstract

Leptin, particularly in its free form, is deeply involved in the regulation of energy balance. Insulin was suggested to influence plasmatic leptin levels and soluble leptin receptor in humans. However, this study indicates that metformin treatment, although improving insulin levels, does not exert a significant effect on either total leptin level or free leptin index in obese women with hyperinsulinemia and PCOS.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Humans
Hyperinsulinism / blood
Hyperinsulinism / complications
Hypoglycemic Agents / pharmacology*
Insulin / blood
Leptin / blood*
Metformin / pharmacology*
Obesity / blood*
Obesity / complications
Polycystic Ovary Syndrome / blood*
Polycystic Ovary Syndrome / complications

Substances

Hypoglycemic Agents
Insulin
Leptin
Metformin