Abstract
Male and female mice from different control strains (C57BL/6, DBA/2, BALB/c) and the nonobese diabetic (NOD) strain, a spontaneous model of type 1 diabetes, were subjected to various stressors (restraint, lipopolysaccharide or interleukin-1 injection). Significant differences were measured among strains in blood glucose, insulin and corticosterone levels and, for restraint, IL-6. Addition of dexamethasone, a glucocorticoid receptor agonist, to inhibit the expression of several proteins by LPS-stimulated bone marrow-derived macrophages in vitro showed a gradient among control strains: C57BL/6>DBA/2>BALB/c corroborating the pattern of corticosensitivity suggested by their stress-induced glucose responses at the systemic level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Animals, Inbred Strains
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Blood Glucose / metabolism*
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Cells, Cultured
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Corticosterone / metabolism*
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Cytokines / metabolism
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Dexamethasone / pharmacology
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Diabetes Mellitus, Type 1 / blood
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Diabetes Mellitus, Type 1 / physiopathology
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Enzyme-Linked Immunosorbent Assay / methods
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Female
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Insulin / blood
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Interleukin-1 / adverse effects
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Interleukin-6 / metabolism
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Macrophages / drug effects
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Macrophages / physiology
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Male
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Mice
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Nitric Oxide Synthase Type II / metabolism
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Polysaccharides / adverse effects
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Restraint, Physical / methods
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Species Specificity
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Stress, Physiological / etiology
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Stress, Physiological / immunology*
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Stress, Physiological / physiopathology*
Substances
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Blood Glucose
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Cytokines
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Insulin
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Interleukin-1
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Interleukin-6
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Polysaccharides
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Dexamethasone
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Nitric Oxide Synthase Type II
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Corticosterone