Brain tau expression and correlation with the H1/H1 tau genotype in frontotemporal lobar degeneration patients

J Neural Transm (Vienna). 2007;114(12):1585-8. doi: 10.1007/s00702-007-0786-5. Epub 2007 Jul 30.

Abstract

Alterations in tau mRNA splicing and association with H1/H1 tau genotype have been described in some sporadic tauopathies. We evaluated the 4R/3R tau mRNA ratio in 18 patients with frontotemporal lobar degeneration (FTLD), and the effect of the H1/H1 genotype on this ratio. The 4R/3R mRNA ratio in frontal cortex was similar in FTLD patients and controls. The H1/H1 genotype carriers showed a significant increase in 4R/3R mRNA ratio, suggesting that this genotype could modulate the tau mRNA splicing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alternative Splicing
  • Brain / pathology*
  • Dementia / genetics*
  • Dementia / pathology*
  • Female
  • Gene Expression
  • Genotype*
  • Humans
  • Male
  • Middle Aged
  • Protein Isoforms / biosynthesis
  • RNA, Messenger / analysis
  • Reverse Transcriptase Polymerase Chain Reaction
  • tau Proteins / biosynthesis
  • tau Proteins / genetics*

Substances

  • Protein Isoforms
  • RNA, Messenger
  • tau Proteins