Cross-reactivity of non-Aspergillus fungal species in the Aspergillus galactomannan enzyme immunoassay

Diagn Microbiol Infect Dis. 2007 Sep;59(1):113-5. doi: 10.1016/j.diagmicrobio.2007.04.022. Epub 2007 Jul 26.

Abstract

The Aspergillus galactomannan enzyme-linked immunosorbant assay (EIA) has been demonstrated to facilitate rapid and sensitive detection of invasive aspergillosis. However, test specificity has not been fully evaluated in non-Aspergillus fungal species. Of 53 fungal isolates, cross-reactivity was observed with 5 non-Aspergillus spp.: Blastomyces dermatitidis, Nigrospora oryzae, Paecilomyces lilacinus, Penicillium chrysogenum, and Trichothecium roseum.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillosis / diagnosis
  • Aspergillus / classification*
  • Cross Reactions
  • Galactose / analogs & derivatives
  • Humans
  • Immunoenzyme Techniques / methods
  • Mannans / classification*
  • Mycological Typing Techniques / methods*
  • Mycoses / diagnosis*
  • Sensitivity and Specificity

Substances

  • Mannans
  • galactomannan
  • Galactose