Cadophora finlandia and Phialocephala fortinii: Agrobacterium-mediated transformation and functional GFP expression

Mycol Res. 2007 Jul;111(Pt 7):850-5. doi: 10.1016/j.mycres.2007.05.002. Epub 2007 May 18.

Abstract

Hygromycin B resistance was transferred to the sterile mycelia of Cadophora finlandia and Phialocephala fortinii by co-cultivation with Agrobacterium tumefaciens. Constitutively expressed green fluorescent protein (GFP) was also introduced using the same vector. Confocal laser scanning microscopy (CLSM) revealed strong fluorescence of transformants. Both traits were mitotically stable during one year of subculturing on non-selective growth medium. Southern blot analysis showed that the majority of the transformants contained single-copy integrations at random sites in the genome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agrobacterium tumefaciens / genetics*
  • Agrobacterium tumefaciens / growth & development
  • Agrobacterium tumefaciens / metabolism
  • Ascomycota / genetics*
  • Ascomycota / growth & development
  • Ascomycota / metabolism
  • Drug Resistance, Fungal / genetics
  • Green Fluorescent Proteins / genetics
  • Green Fluorescent Proteins / metabolism*
  • Hygromycin B / pharmacology
  • Microscopy, Confocal
  • Transformation, Genetic*

Substances

  • Green Fluorescent Proteins
  • Hygromycin B