Fatal brain infection caused by Aspergillus glaucus in an immunocompetent patient identified by sequencing of the ribosomal 18S-28S internal transcribed spacer

R S Traboulsi; M M Kattar; O Dbouni; G F Araj; S S Kanj

doi:10.1007/s10096-007-0361-x

Fatal brain infection caused by Aspergillus glaucus in an immunocompetent patient identified by sequencing of the ribosomal 18S-28S internal transcribed spacer

Eur J Clin Microbiol Infect Dis. 2007 Oct;26(10):747-50. doi: 10.1007/s10096-007-0361-x.

Authors

R S Traboulsi¹, M M Kattar, O Dbouni, G F Araj, S S Kanj

Affiliation

¹ Division of Infectious Diseases, American University of Beirut Medical Center, P.O. Box 113-6044, Hamra, Beirut, 110 32090, Lebanon.

PMID: 17665232
DOI: 10.1007/s10096-007-0361-x

Abstract

Cerebral aspergillosis has rarely been reported in immunocompetent patients. We herein describe a unique case of cerebral aspergillosis in a healthy adult that led to his death despite aggressive antifungal therapy. Sequencing of ribosomal 18S-28S internal transcribed spacer identified the organism as Eurotium herbariorum, the teleomorph of Aspergillus glaucus.

Publication types

Case Reports

MeSH terms

Adult
Aspergillus / genetics*
Aspergillus / isolation & purification
Brain Diseases / drug therapy
Brain Diseases / immunology
Brain Diseases / microbiology*
DNA, Ribosomal Spacer / genetics
Fatal Outcome
Humans
Immunocompetence
Male
Neuroaspergillosis / drug therapy
Neuroaspergillosis / immunology
Neuroaspergillosis / microbiology*
RNA, Ribosomal, 18S / genetics*
RNA, Ribosomal, 28S / genetics*

Substances

DNA, Ribosomal Spacer
RNA, Ribosomal, 18S
RNA, Ribosomal, 28S