Abstract
Amphotericin B and flucytosine (5FC) have an additive effect when used for disseminated candidiasis. Here, we bridge the results of an experimental pharmacodynamic study to humans and demonstrate that a 5FC dosage of 25 mg/kg of body weight/day in four divided doses in combination with amphotericin B produces near-maximal effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Algorithms
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Amphotericin B / pharmacokinetics
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Amphotericin B / therapeutic use*
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Antifungal Agents / administration & dosage*
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Antifungal Agents / pharmacokinetics
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Antifungal Agents / therapeutic use*
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Area Under Curve
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Candidiasis / drug therapy*
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Candidiasis / microbiology
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Child
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Drug Interactions
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Flucytosine / administration & dosage*
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Flucytosine / pharmacokinetics
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Flucytosine / therapeutic use*
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Humans
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Models, Statistical
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Monte Carlo Method
Substances
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Antifungal Agents
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Amphotericin B
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Flucytosine