Acute T lymphoid and megakaryoblastic bi-lineal leukemia in a child

Upendra Srinivas; Renu Saxena; Sameer Bakhshi

Acute T lymphoid and megakaryoblastic bi-lineal leukemia in a child

Indian Pediatr. 2007 Jul;44(7):541-3.

Authors

Upendra Srinivas¹, Renu Saxena, Sameer Bakhshi

Affiliation

¹ Departments of Hematology and Medical Oncology, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110 029, India.

PMID: 17684307

Abstract

A 1 1/2-year-old boy presented with fever, anemia, petechial rash and hepatosplenomegaly. Bone marrow examination showed two morphologically distinct blasts (small and large) which were confirmed on immunophenotyping to be of T-lymphoid and megakaryocytic lineages respectively. Patient was refractory to therapy. This is a rare combination of bi-lineal leukemia in a child.

Publication types

Case Reports

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Fatal Outcome
Hepatomegaly / etiology
Humans
Infant
Leukemia, Megakaryoblastic, Acute / diagnosis
Leukemia, Megakaryoblastic, Acute / drug therapy
Leukemia, Megakaryoblastic, Acute / pathology*
Leukemia-Lymphoma, Adult T-Cell / diagnosis
Leukemia-Lymphoma, Adult T-Cell / drug therapy
Leukemia-Lymphoma, Adult T-Cell / pathology*
Male
Megakaryocytes / pathology
Splenomegaly / etiology
T-Lymphocytes / pathology