A degradation product of halobetasol propionate: characterization and structure

Giancarlo Cravotto; Giovanni B Giovenzana; Norberto Masciocchi; Giovanni Palmisano; Paolo Volante

doi:10.1016/j.steroids.2007.06.003

A degradation product of halobetasol propionate: characterization and structure

Steroids. 2007 Oct;72(11-12):787-91. doi: 10.1016/j.steroids.2007.06.003. Epub 2007 Jul 3.

Authors

Giancarlo Cravotto¹, Giovanni B Giovenzana, Norberto Masciocchi, Giovanni Palmisano, Paolo Volante

Affiliation

¹ Dipartimento di Scienza e Tecnologia del Farmaco, Via Giuria 9, 10125, Torino, Italy.

PMID: 17686501
DOI: 10.1016/j.steroids.2007.06.003

Abstract

Degradation of halobetasol propionate was observed in the presence of bases. A single cyclization product was isolated and fully characterized by MS, NMR and X-ray crystallography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Clobetasol / analogs & derivatives*
Clobetasol / chemistry
Clobetasol / metabolism
Crystallography, X-Ray
Cyclization
Magnetic Resonance Spectroscopy
Models, Molecular
Vasoconstrictor Agents / chemistry*
Vasoconstrictor Agents / metabolism*

Substances

Vasoconstrictor Agents
halobetasol
Clobetasol