Abstract
We experienced a case of good response in acute respiratory distress syndrome (ARDS) treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma. A 66-year-old male treated with combined paclitaxel (PTX) and S-1 suffered from ARDS following neutropenia. Sputum and blood culture examinations demonstrated an unknown origin, so sivelestat sodium hydrate was considered more effective than antibiotics. Sivelestat sodium hydrate ought to be used for ARDS treatment even during administration of anti-cancer agent.
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bile Duct Neoplasms / drug therapy*
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Bile Ducts, Intrahepatic*
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Cholangiocarcinoma / drug therapy*
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Drug Administration Schedule
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Drug Combinations
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Glycine / analogs & derivatives*
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Glycine / therapeutic use
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Humans
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Male
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Neutropenia / etiology
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Oxonic Acid / administration & dosage
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Paclitaxel / administration & dosage
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Respiratory Distress Syndrome / drug therapy*
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Respiratory Distress Syndrome / etiology
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Serine Proteinase Inhibitors / therapeutic use*
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Sulfonamides / therapeutic use*
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Tegafur / administration & dosage
Substances
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Drug Combinations
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Serine Proteinase Inhibitors
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Sulfonamides
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S 1 (combination)
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Tegafur
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Oxonic Acid
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sivelestat
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Paclitaxel
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Glycine