Alcohol- and substance-dependent subjects: the correlated factors in qualifying for liver transplantation

Transplant Proc. 2007 Jul-Aug;39(6):1861-3. doi: 10.1016/j.transproceed.2007.05.024.

Abstract

Objectives: To identify the most significant variables in determining if candidates with past or current addictions can be considered for liver transplantation.

Methods: Data relating to 58 cases from January 2001 to December 2003 were collected and analyzed.

Results: The decisional algorithm identified by discriminant analysis is based on the following variables: the duration of remission, treatment adherence, and the presence of a valid help relationship. Candidates undergoing initial remission (up to 12 months) must demonstrate both adherence and affective support; those with over 5 years of remission, however, are considered sufficiently reliable. A positive judgment is significantly correlated to overall survival and clinical improvement even without transplantation.

Conclusions: In toxicological evaluation, treatment adherence and the presence of a valid help relationship for patients in remission from addictions can improve the selection criteria for liver transplantation, making it more dependable.

MeSH terms

  • Alcoholism*
  • Algorithms
  • Humans
  • Liver Transplantation / mortality
  • Liver Transplantation / statistics & numerical data*
  • Patient Selection*
  • Substance-Related Disorders*
  • Treatment Outcome
  • Waiting Lists*