Rapid development of multiple squamous-cell carcinomas during chronic granulocytic leukemia

P Disdier; J R Harle; J J Grob; C Weiller-Merli; G Magalon; P J Weiller

doi:10.1159/000247631

Rapid development of multiple squamous-cell carcinomas during chronic granulocytic leukemia

Dermatologica. 1991;183(1):47-8. doi: 10.1159/000247631.

Authors

P Disdier¹, J R Harle, J J Grob, C Weiller-Merli, G Magalon, P J Weiller

Affiliation

¹ Service de Médecine Interne du Prof. P.J. Weiller, Clinique Médicale B, Hôpital de La Timone, France.

PMID: 1769415
DOI: 10.1159/000247631

Abstract

We report a 65-year-old patient who presented a rapid eruption of keratoses on sun-exposed areas and an explosive transformation into several squamous-cell carcinomas, occurring during the accelerated phase of a chronic granulocytic leukemia. Clinical findings resembled those usually described in xeroderma pigmentosum. The role of immunosuppression, chemotherapy and possible genetic predisposition is discussed.

Publication types

Case Reports

MeSH terms

Aged
Antineoplastic Agents / adverse effects
Carcinoma, Squamous Cell* / chemically induced
Carcinoma, Squamous Cell* / pathology
Humans
Immunocompromised Host
Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / immunology
Male
Neoplasms, Multiple Primary* / chemically induced
Neoplasms, Multiple Primary* / pathology
Skin Neoplasms* / chemically induced
Skin Neoplasms* / pathology

Substances

Antineoplastic Agents