Endovascular cooling in a patient with neuroleptic malignant syndrome

J Neurol Sci. 2008 Jan 15;264(1-2):163-5. doi: 10.1016/j.jns.2007.06.052. Epub 2007 Aug 16.

Abstract

We report a case of severe neuroleptic malignant syndrome with hyperthermia, rhabdomyolysis and hepatic failure where we applied endovascular cooling in order to reverse hyperthermia. After rapid normalization of core temperature at 37.5 degrees C, the patient's condition improved and CK levels dropped. However, upon withdrawl of endovascular temperature control there was a relapse. This is the first case where endovascular cooling was applied successfully in neuroleptic malignant syndrome.

Publication types

  • Case Reports

MeSH terms

  • Antipsychotic Agents / poisoning
  • Catheters, Indwelling
  • Creatine Kinase / blood
  • Drug Synergism
  • Female
  • Fever / chemically induced*
  • Fever / physiopathology
  • Fever / therapy*
  • Haloperidol / poisoning*
  • Histamine H1 Antagonists / poisoning
  • Humans
  • Hypothermia, Induced / methods*
  • Liver Failure, Acute / chemically induced
  • Liver Failure, Acute / physiopathology
  • Middle Aged
  • Neuroleptic Malignant Syndrome / complications*
  • Neuroleptic Malignant Syndrome / physiopathology*
  • Promethazine / poisoning*
  • Recurrence
  • Rhabdomyolysis / chemically induced
  • Rhabdomyolysis / physiopathology
  • Suicide, Attempted
  • Treatment Outcome

Substances

  • Antipsychotic Agents
  • Histamine H1 Antagonists
  • Creatine Kinase
  • Promethazine
  • Haloperidol