Cooperativity in glycan-protein interactions

Rahul Raman; Ram Sasisekharan

doi:10.1016/j.chembiol.2007.08.003

Cooperativity in glycan-protein interactions

Chem Biol. 2007 Aug;14(8):873-4. doi: 10.1016/j.chembiol.2007.08.003.

Authors

Rahul Raman¹, Ram Sasisekharan

Affiliation

¹ Department of Biological Engineering, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

PMID: 17719484
DOI: 10.1016/j.chembiol.2007.08.003

Abstract

Using FGF-2 HSGAGs as a model, de Paz and colleagues [1] have demonstrated the importance of multivalency in cooperative glycan-protein interactions to achieve specificity.

Publication types

Comment
Research Support, N.I.H., Extramural

MeSH terms

Heparan Sulfate Proteoglycans / biosynthesis
Heparan Sulfate Proteoglycans / metabolism*
Protein Binding
Proteins / metabolism*

Substances

Heparan Sulfate Proteoglycans
Proteins

Grants and funding

GM57073/GM/NIGMS NIH HHS/United States