Abstract
We briefly survey recent basic progress on the structure and function of MHC molecules. We call attention on a number of remaining unanswered questions, and focus on a few points which we think might be of importance in immune surveillance against tumors mediated by MHC restricted T cells. In particular, we discuss the possible peptidic nature of certain tumor antigens. Following these lines, we mention a recent approach for the in vivo activation of specific CTL.
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology
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Antigens, Neoplasm / immunology*
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Antigens, Neoplasm / metabolism
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HLA Antigens / immunology
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HLA Antigens / metabolism
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Histocompatibility Antigens / immunology*
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Histocompatibility Antigens / metabolism
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Humans
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Immune Tolerance
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Immunologic Surveillance
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Immunotherapy
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Models, Biological
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Neoplasms / immunology*
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Neoplasms / therapy
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Neoplasms, Experimental / immunology
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Peptide Fragments / immunology
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Protein Conformation
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Receptors, Antigen, T-Cell / immunology
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Antigens, Neoplasm
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HLA Antigens
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Histocompatibility Antigens
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Peptide Fragments
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Receptors, Antigen, T-Cell