Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives

Sajal Kumar Das; Gautam Panda; Vinita Chaturvedi; Y S Manju; Anil K Gaikwad; Sudhir Sinha

doi:10.1016/j.bmcl.2007.07.089

Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5586-9. doi: 10.1016/j.bmcl.2007.07.089. Epub 2007 Aug 22.

Authors

Sajal Kumar Das¹, Gautam Panda, Vinita Chaturvedi, Y S Manju, Anil K Gaikwad, Sudhir Sinha

Affiliation

¹ Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.

PMID: 17764933
DOI: 10.1016/j.bmcl.2007.07.089

Abstract

A new series of diarylmethylnapthyloxy ethylamines were synthesized by aminoalkylation of diarylmethylnaphthols which were obtained by Friedel-Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25 microg/ml.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis*
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology*
Drug Design*
Methylation
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Naphthols / chemical synthesis*
Naphthols / chemistry
Naphthols / pharmacology*
Structure-Activity Relationship

Substances

Antitubercular Agents
Naphthols