Severe, obstructive biventricular hypertrophy in a patient with Costello syndrome: Clinical impact and management

Giuseppe Limongelli; Giuseppe Pacileo; Maria Cristina Digilio; Paolo Calabro'; Giovanni Di Salvo; Alessandra Rea; Tiziana Miele; Alessandro Frigiola; Anna Sarkozy; Bruno Dallapiccola; Bruno Marino; Raffaele Calabro'

doi:10.1016/j.ijcard.2007.06.107

Severe, obstructive biventricular hypertrophy in a patient with Costello syndrome: Clinical impact and management

Int J Cardiol. 2008 Nov 28;130(3):e108-10. doi: 10.1016/j.ijcard.2007.06.107. Epub 2007 Aug 31.

Authors

Giuseppe Limongelli, Giuseppe Pacileo, Maria Cristina Digilio, Paolo Calabro', Giovanni Di Salvo, Alessandra Rea, Tiziana Miele, Alessandro Frigiola, Anna Sarkozy, Bruno Dallapiccola, Bruno Marino, Raffaele Calabro'

PMID: 17765343
DOI: 10.1016/j.ijcard.2007.06.107

Abstract

We report a severe, biventricular obstructive cardiomyopathy in a young female with Costello syndrome, who underwent a right ventricular myectomy for symptoms relief. We discuss potential clinical implications and management of severe hypertrophy in Costello syndrome.

Publication types

Case Reports
Letter

MeSH terms

Abnormalities, Multiple / genetics
Abnormalities, Multiple / pathology*
Adolescent
Adrenergic beta-Antagonists / therapeutic use*
Cardiomegaly / drug therapy*
Cardiomegaly / genetics
Cardiomegaly / pathology*
Female
Humans
Intellectual Disability / genetics
Intellectual Disability / pathology
Phenotype
Proto-Oncogene Proteins p21(ras) / genetics
Severity of Illness Index
Syndrome*

Substances

Adrenergic beta-Antagonists
HRAS protein, human
Proto-Oncogene Proteins p21(ras)