The criteria for the diagnosis of the atypical facial neuralgia make it is possible to classify under this neurological diagnosis also psychiatric disorders as conasthetic depression. In two case reports it is told about patients with both diagnosis. Due to this they were treated with an atypical neurolepticum (Olanzapine) to reach three targets: Therapy of the depression, pain i.e. atypical facial neuralgia and mood stabilizing. Within the last four years there were no side-effects as EPMS to observe.