Abstract
We compared the E2-HVR1 region in HCV-1b positive B-NHL cases from a multicenter study with sequences from studies related to lymphoproliferative disorders and B cell compartmentalisation. We found rare and unique mutations both in B-NHL isolates and in cases with lymphoproliferative disorders and lymphocyte infection. These rare mutations could have an important effect on HVR1 region and, as a consequence, on the binding of E2 on CD81, with a possible implication for both antigenic stimulation and HCV entry. In conclusion, the HCV predominants circulating in B-NHL cases seem to be associated with clonal selection of rare variants.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, CD / metabolism
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Genetic Variation
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Hepacivirus / classification
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Hepacivirus / genetics*
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Hepatitis C / complications
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Hepatitis C / virology*
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Hepatitis C Antigens / genetics
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Hepatitis C Antigens / metabolism
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Humans
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Italy
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Lymphoma, B-Cell / complications
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Lymphoma, B-Cell / virology*
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Molecular Sequence Data
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Selection, Genetic
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Species Specificity
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Tetraspanin 28
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Viral Envelope Proteins / genetics
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Viral Envelope Proteins / metabolism
Substances
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Antigens, CD
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CD81 protein, human
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Hepatitis C Antigens
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Tetraspanin 28
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Viral Envelope Proteins
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glycoprotein E2, Hepatitis C virus
Associated data
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GENBANK/DQ463307
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GENBANK/DQ463308
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GENBANK/DQ463309
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GENBANK/DQ463310
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GENBANK/DQ463311
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GENBANK/DQ463312
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GENBANK/DQ463313
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GENBANK/DQ463314
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GENBANK/DQ463315
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GENBANK/DQ463316
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GENBANK/DQ463317
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GENBANK/DQ463318
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GENBANK/DQ463319
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GENBANK/DQ463320