Childhood acute myeloid leukemia with hemophagocytosis by the blasts and inv(8)(p11q13) with MOZ-TIF2 fusion transcripts

Mohamed Abdelhaleem; Mary Shago; Kassa Beimnet; Ebrahim Sayeh; Sandip Bartakke; Sheila Weitzman

doi:10.1097/MPH.0b013e318142b547

Childhood acute myeloid leukemia with hemophagocytosis by the blasts and inv(8)(p11q13) with MOZ-TIF2 fusion transcripts

J Pediatr Hematol Oncol. 2007 Sep;29(9):643-5. doi: 10.1097/MPH.0b013e318142b547.

Authors

Mohamed Abdelhaleem¹, Mary Shago, Kassa Beimnet, Ebrahim Sayeh, Sandip Bartakke, Sheila Weitzman

Affiliation

¹ Division of Haematopathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada. [email protected]

PMID: 17805042
DOI: 10.1097/MPH.0b013e318142b547

Abstract

We describe a unique case of de novo childhood acute myeloid leukemia in which the blasts showed evidence of hemophagocytosis and harbored inv(8) (p11q13) chromosomal abnormality. Reverse-transcription polymerase chain reaction showed the presence of 2 MOZ-TIF2 fusion transcripts. To our knowledge, this is the eighth overall and the fourth childhood case of acute myeloid leukemia with inv(8) (p11q13) with MOZ-TIF2 fusion.

Publication types

Case Reports

MeSH terms

Acute Disease
Child
Chromosome Aberrations*
Chromosomes, Human, Pair 11 / genetics*
Female
Humans
Leukemia, Myeloid / diagnosis
Leukemia, Myeloid / genetics*
Leukemia, Myeloid / pathology
Lymphohistiocytosis, Hemophagocytic / diagnosis
Lymphohistiocytosis, Hemophagocytic / genetics*
Lymphohistiocytosis, Hemophagocytic / pathology
Oncogene Proteins, Fusion / genetics*
Transcription, Genetic

Substances

MOZ-TIF2 protein, human
Oncogene Proteins, Fusion