Study of the skin concentrations after administration of the various phototoxic drugs

Yonsei Med J. 1991 Sep;32(3):231-6. doi: 10.3349/ymj.1991.32.3.231.

Abstract

The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and 4, 5', 8-trimethylpsoralen (TMP) were studied in the guinea pig following oral administration and bathing. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 hours, and the concentration of 8-MOP was 3.5 times greater than that of 5-MOP. The skin concentration of TMP was not detected in our study (limit of sensitivity 5ng/ml). The skin concentrations of phototoxic drug after bathing decreased in the order of 5-MOP, TMP, and 8-MOP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Animals
  • Guinea Pigs
  • Methoxsalen / administration & dosage
  • Methoxsalen / analysis*
  • PUVA Therapy
  • Skin / chemistry*
  • Trioxsalen / administration & dosage
  • Trioxsalen / analysis*

Substances

  • Methoxsalen
  • Trioxsalen