Abstract
A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.
Publication types
-
Research Support, N.I.H., Intramural
MeSH terms
-
Enzyme Inhibitors / chemistry*
-
Enzyme Inhibitors / pharmacology*
-
Gaucher Disease / enzymology*
-
Glucosylceramidase / antagonists & inhibitors*
-
Humans
-
Triazines / chemistry*
-
Triazines / pharmacology*
Substances
-
Enzyme Inhibitors
-
Triazines
-
Glucosylceramidase