Abstract
In vitro data suggest valproate activates HIV replication. This study prospectively assesses whether divalproex sodium causes an increase in HIV replication in patients. Eight participants had their HIV viral load measured over approximately 1 month. The largest increases in viral load occurred in patients without antiretroviral medication. No patients had an increase in Log10 HIV viral load > or = 0.5. Further study is needed to understand implications.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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CD4 Lymphocyte Count
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Enzyme Inhibitors / pharmacology*
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Enzyme Inhibitors / therapeutic use
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Female
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HIV / physiology*
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HIV Infections / drug therapy
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Humans
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Male
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Middle Aged
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Prospective Studies
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Retrospective Studies
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Valproic Acid / administration & dosage
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Valproic Acid / pharmacology*
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Valproic Acid / therapeutic use
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Viral Load
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Virus Replication / drug effects*
Substances
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Enzyme Inhibitors
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Valproic Acid