Candida albicans biofilms produce more secreted aspartyl protease than the planktonic cells

Aline Mendes; Alinne Ulbrich Mores; Alessandra Paula Carvalho; Rosimeire Takaki Rosa; Lakshman Perera Samaranayake; Edvaldo Antonio Ribeiro Rosa

doi:10.1248/bpb.30.1813

Candida albicans biofilms produce more secreted aspartyl protease than the planktonic cells

Biol Pharm Bull. 2007 Sep;30(9):1813-5. doi: 10.1248/bpb.30.1813.

Authors

Aline Mendes¹, Alinne Ulbrich Mores, Alessandra Paula Carvalho, Rosimeire Takaki Rosa, Lakshman Perera Samaranayake, Edvaldo Antonio Ribeiro Rosa

Affiliation

¹ Laboratory of Stomatology, Faculty of Dentistry, Pontifical Catholic University of Paraná, Brazil.

PMID: 17827747
DOI: 10.1248/bpb.30.1813

Abstract

By using a simple, low-cost system of polystyrene centrifuge tubes we compared the secreted aspartyl proteases (Saps) secretion during the biphasic growth modes of Candida albicans using twenty-one clinical isolates. Our results indicate that biofilms of C. albicans consistently secrete more Saps than their planktonic counterparts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aspartic Acid Endopeptidases / metabolism*
Biofilms*
Biomass
Candida albicans / enzymology*
Candida albicans / growth & development
Candida albicans / physiology
Mitochondria / enzymology
Tetrazolium Salts

Substances

Tetrazolium Salts
2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazolium hydroxide
Aspartic Acid Endopeptidases