Abstract
A series of indolopyrrolemaleimides have been synthesized and evaluated for their cytotoxicity in vitro against human leukemia cell line and four human solid cancer cell lines. Some of the compounds showed high or mediate activity against the lines. 6dc is the most promising compound among them. The inhibition toward topoisomerase I was also studied.
MeSH terms
-
Animals
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology*
-
Cattle
-
Cell Line, Tumor
-
DNA, Superhelical / drug effects
-
Drug Screening Assays, Antitumor
-
Enzyme Inhibitors / chemical synthesis
-
Enzyme Inhibitors / pharmacology
-
HL-60 Cells
-
Humans
-
Indicators and Reagents
-
Indoles / chemical synthesis*
-
Indoles / pharmacology*
-
Maleimides / chemical synthesis*
-
Maleimides / pharmacology*
-
Topoisomerase II Inhibitors
Substances
-
Antineoplastic Agents
-
DNA, Superhelical
-
Enzyme Inhibitors
-
Indicators and Reagents
-
Indoles
-
Maleimides
-
Topoisomerase II Inhibitors