Genetics of psoriasis and psoriatic arthritis

A Mathieu; A Cauli; A Vacca; A Mameli; G Passiu; G Porru; M Piga; V Ibba; V Mura; S Sanna

doi:10.4081/reumatismo.2007.1s.25

Genetics of psoriasis and psoriatic arthritis

Reumatismo. 2007:59 Suppl 1:25-7. doi: 10.4081/reumatismo.2007.1s.25.

Authors

A Mathieu¹, A Cauli, A Vacca, A Mameli, G Passiu, G Porru, M Piga, V Ibba, V Mura, S Sanna

Affiliation

¹ Rheumatology Unit, University of Cagliari, Monserrato, Cagliari, Italy.

PMID: 17828355
DOI: 10.4081/reumatismo.2007.1s.25

Abstract

Psoriasis and psoriatic arthritis are linked diseases characterised by (distinct ?) immune-mediated pathogenetic mechanisms and by a genetic background interacting with environmental factors. Some candidate susceptibility genes have been studied extensively; they include HLA genes, genes within the HLA region and genes outside the HLA region; among them corneodesmosin and other genes of PSORS1 region, MICA and TNF-a polymorphisms. The main findings in the literature are discussed.

Publication types

Review

MeSH terms

Alleles
Arthritis, Psoriatic / genetics
Genetic Markers / genetics
Genetic Predisposition to Disease
Genotype
HLA-C Antigens / genetics
Histocompatibility Antigens Class I / genetics
Humans
Polymorphism, Genetic
Proteins / genetics
Psoriasis / genetics*
Psoriasis / immunology
Tumor Necrosis Factor-alpha / genetics

Substances

Genetic Markers
HLA-C Antigens
Histocompatibility Antigens Class I
MHC class I-related chain A
PSORS1C1 protein, human
Proteins
Tumor Necrosis Factor-alpha