Systemic scleroderma (SSc) is a rare, heterogenous, multisystem disease affecting different organ systems and therefore requires interdisciplinary management and patient care. The German Network for Systemic Scleroderma, funded by the country's Federal Ministry of Education and Research, was established 3 years ago and comprises dermatologists, rheumatologists, pulmonologists, and nephrologists from more than 40 medical centers. The registry contains data of more than 1800 patients. Analysis of the continually growing body of data will form the basis for the development of standardized recommendations for diagnosis and treatment of SSc.