In this two-wave prospective study, the authors investigated whether level of dispositional affective empathy moderated the association between parental support and antisocial behavior in early adolescents. The sample consisted of 823 Dutch boys and girls (mean age = 12.8 years) enrolled in the first year of secondary education. Higher levels of affective empathy were associated with less delinquent and aggressive behavior. Contrary to expectations, structural equation modeling did not indicate that youth with higher levels of affective empathy were susceptible to parental support. Further analyses showed that gender moderated the association between parental support and future delinquent and aggressive behavior. Only for girls, were high levels of parental support associated with lower levels of antisocial behavior.