Detection of Aspergillus carbonarius and other black aspergilli from grapes by DNA OLISA microarray

Food Addit Contam. 2007 Oct;24(10):1138-47. doi: 10.1080/02652030701579447.

Abstract

Black aspergilli, and particularly Aspergillus carbonarius, are responsible for ochratoxin A production in grapes. Correct identification of these species is essential for toxicological risk assessment in grape and wine. A low-complexity oligonucleotide microarray (OLISA, Apibio, F) based on DNA oligonucleotides probes, obtained from sequences of the calmodulin gene, was set up in order to detect A. carbonarius, A. japonicus/A. aculeatus and A. ibericus isolated from grape. The designed microarray distinguished all Aspergillus species and the detection limit for A. carbonarius was 3.2 pg of DNA as a template for the PCR reaction. This microarray offers a quick and parallel analysis to detect individual Aspergillus species in pure cultures and in naturally contaminated grape samples.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus / classification
  • Aspergillus / genetics
  • Aspergillus / isolation & purification*
  • DNA, Fungal / genetics
  • Food Contamination / analysis
  • Food Microbiology
  • Gene Expression
  • Ochratoxins / biosynthesis*
  • Oligonucleotide Array Sequence Analysis / methods*
  • Polymerase Chain Reaction / methods
  • Species Specificity
  • Vitis / microbiology*

Substances

  • DNA, Fungal
  • Ochratoxins
  • ochratoxin A