Abstract
Based on a pharmacophore alignment on a 5-HT(6) ligand applying 4SCan technology, a new lead series was identified and further structurally investigated. K(i)s down to 8 nM were achieved.
MeSH terms
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Aniline Compounds / chemistry*
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Aniline Compounds / pharmacology
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Computer Simulation*
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Drug Design
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Humans
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Indoles / chemistry
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Indoles / pharmacology
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Ligands
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Models, Molecular
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Molecular Structure
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Piperazine
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Piperazines / chemistry*
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Piperazines / pharmacology
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Receptors, Serotonin / chemistry*
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / metabolism
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Software
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Structure-Activity Relationship
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Sulfonamides / chemistry*
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Sulfonamides / pharmacology
Substances
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Aniline Compounds
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Indoles
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Ligands
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N-(3-(2-dimethylaminoethyl)-1H-indol-5-yl)-5-chloronaphthalene-2-sulfonamide
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Piperazines
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Receptors, Serotonin
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Sulfonamides
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serotonin 6 receptor
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Piperazine
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aniline