Early average change in tumor size in a phase 2 trial: efficient endpoint or false promise?

MeSH terms

• Antineoplastic Agents / therapeutic use*
• Clinical Trials, Phase II as Topic / methods*
• Disease Progression
• Disease-Free Survival
• Endpoint Determination / methods*
• Humans
• Neoplasms / drug therapy*
• Randomized Controlled Trials as Topic / methods*
• Research Design
• Sample Size*
• Treatment Outcome