5-HT7 receptor ligands: recent developments and potential therapeutic applications

Mini Rev Med Chem. 2007 Sep;7(9):945-60. doi: 10.2174/138955707781662663.

Abstract

The 5-HT(7) receptors (5-HT(7)Rs) are the most recent classified members of the serotonin family. Characterized in 1993, they belong to the G protein-coupled receptor family. Since their discovery, they have been the subject of intense research due to their widespread distribution in the brain, suggestive of multiple central roles. The focus of this review is to discuss the literature concerning recent advances on 5-HT(7)Rs and their ligands.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Ligands
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / metabolism
  • Serotonin Agents / metabolism
  • Serotonin Agents / pharmacology*

Substances

  • Ligands
  • Receptors, Serotonin
  • Serotonin Agents
  • serotonin 7 receptor