Objective: To identify biofilm formation within a case of temporal bone osteoradionecrosis.
Patient: Single-case patient presenting with temporal bone osteoradionecrosis.
Intervention(s): Antibiotic therapy and then surgical debridement of the temporal bone.
Main outcome measure(s): Histologic identification of biofilm formation within the affected temporal bone specimen.
Results: Positive identification of biofilm formation in multiple sections of the temporal bone specimen removed from a patient affected by osteoradionecrosis.
Conclusion: This is the first evidence that temporal bone osteoradionecrosis involves biofilm formation. Such a pathogenic mechanism may explain the recalcitrance of this disease process and offer new strategies in formulating therapeutic interventions.