Coenzyme biosynthesis: enzyme mechanism, structure and inhibition

Nat Prod Rep. 2007 Oct;24(5):1009-26. doi: 10.1039/b703108b. Epub 2007 Aug 28.

Abstract

This review highlights five key reactions in vitamin biosynthesis and in particular focuses on their mechanisms and inhibition and insights from structural studies. Each of the enzymes has the potential to be a target for novel antimicrobial agents.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents*
  • Coenzymes* / biosynthesis
  • Coenzymes* / chemistry
  • Coenzymes* / metabolism
  • Enzymes* / drug effects
  • Enzymes* / metabolism
  • Molecular Structure
  • Vitamins* / biosynthesis
  • Vitamins* / chemistry
  • Vitamins* / metabolism

Substances

  • Anti-Infective Agents
  • Coenzymes
  • Enzymes
  • Vitamins