Abstract
In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Bacterial Toxins / metabolism
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CD8-Positive T-Lymphocytes / drug effects
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CD8-Positive T-Lymphocytes / metabolism
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Case-Control Studies
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Cytokines / metabolism
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Female
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Flow Cytometry / methods
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / physiology*
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Heat-Shock Proteins / metabolism
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Hemolysin Proteins / metabolism
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Humans
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Leptin / administration & dosage
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Leptin / blood*
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Male
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Middle Aged
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Monocytes / metabolism
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Multiple Sclerosis, Relapsing-Remitting / blood*
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Multiple Sclerosis, Relapsing-Remitting / pathology
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Radioimmunoassay / methods
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Receptors, Leptin / metabolism*
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STAT3 Transcription Factor / metabolism*
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Sex Factors
Substances
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Bacterial Toxins
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Cytokines
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Heat-Shock Proteins
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Hemolysin Proteins
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Leptin
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Receptors, Leptin
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STAT3 Transcription Factor
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STAT3 protein, human
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hlyA protein, Listeria monocytogenes