Association of genetic markers within the BMP15 gene with anovulation and infertility in women with polycystic ovary syndrome

Alejandro Gónzalez; Reposo Ramírez-Lorca; Carmen Calatayud; Nicolás Mendoza; Agustín Ruiz; Maria Eugenia Sáez; Francisco Jesús Morón

doi:10.1016/j.fertnstert.2007.06.083

Association of genetic markers within the BMP15 gene with anovulation and infertility in women with polycystic ovary syndrome

Fertil Steril. 2008 Aug;90(2):447-9. doi: 10.1016/j.fertnstert.2007.06.083. Epub 2007 Oct 1.

Authors

Alejandro Gónzalez¹, Reposo Ramírez-Lorca, Carmen Calatayud, Nicolás Mendoza, Agustín Ruiz, Maria Eugenia Sáez, Francisco Jesús Morón

Affiliation

¹ Unidad de Reproducción y Genética Humana, Centro Avanzado de Fertilidad, Jerez de la Frontera, Spain.

PMID: 17905236
DOI: 10.1016/j.fertnstert.2007.06.083

Abstract

We analyzed two polymorphisms (-9C>G and IVS1+905A>G) within the BMP15 gene in women from Spain with polycystic ovary syndrome (PCOS). In this study, the BMP15 gene does not seem to be associated with PCOS. Nonetheless, we observed in both markers a genetic association with anovulation or infertility in these patients.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Anovulation / genetics*
Bone Morphogenetic Protein 15
Female
Genetic Markers / physiology*
Growth Differentiation Factor 9
Humans
Infertility, Female / genetics*
Intercellular Signaling Peptides and Proteins / genetics*
Polycystic Ovary Syndrome / genetics*
Polymorphism, Single Nucleotide

Substances

BMP15 protein, human
Bone Morphogenetic Protein 15
GDF9 protein, human
Genetic Markers
Growth Differentiation Factor 9
Intercellular Signaling Peptides and Proteins