Treating ischemic heart disease requires an understanding of both coronary artery anatomy as well as myocardial physiology. The following clinical vignette illustrates these complementary concepts as part of an ongoing series on cardiovascular imaging in the Journal of Cardiovascular Medicine. This series seeks to present contemporary approaches to diagnosis and management in cardiovascular medicine that include state-of-the-art imaging techniques guided by bedside clinical assessment. Incorporating volumetric multidetector computed tomography and dynamic magnetic resonance imaging at various stages of this patient's care afforded timely myocardial characterization and coronary artery intervention.