Abstract
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dermoid Cyst / genetics
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Dermoid Cyst / veterinary*
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Dog Diseases / genetics*
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Dogs
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Female
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Fibroblast Growth Factor 3 / genetics
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Fibroblast Growth Factor 4 / genetics
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Fibroblast Growth Factors / genetics*
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Gene Duplication*
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Genetic Predisposition to Disease*
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Genotype
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Male
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Neoplasm Proteins / genetics
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Phenotype
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Skin Abnormalities / genetics*
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Skin Abnormalities / pathology
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Spina Bifida Occulta / genetics
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Spina Bifida Occulta / veterinary*
Substances
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Fibroblast Growth Factor 3
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Fibroblast Growth Factor 4
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Neoplasm Proteins
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Fibroblast Growth Factors