Objectives: This study was designed to determine the relationship between pulmonary artery (PA) volumes at computed tomography (CT) and PA pressures at right-sided heart catheterization in patients with and without pulmonary hypertension (PAH) to develop a noninvasive CT method of PA pressure quantification.
Materials and methods: Sixteen patients with chronic sleep apnea syndrome underwent contrast enhanced helical CT (slice thickness 3mm; pitch 2; increment 2mm) at inspiration. Eight patients had PAH while cardiopulmonary disease has been excluded in eight other patients. Vascular volumes were determined using a 3D technique (threshold seeded vascular tracing algorithm; thresholds -600 H [lower] and 3,000 H [upper]). Right-sided heart catheterization measurements were available for linear regression analysis of PA volumes and pressures.
Results: Correlation between PA pressures and volumes (normalized for BMI), was high in both groups (without PAH: r=.85; with PAH .90, Pearson). Compared to elevated PA pressures in patients with pulmonary hypertension (p<.005), PA volumes also were significantly increased (p<.05) among the groups.
Conclusions: High correlation was found between PA volumes and mean PA pressures in patients with- and without PAH. Significant differences in PA volumes at CT-volumetry may admit non-invasive determination of pulmonary hypertension.