Abstract
A new sesquiterpene hydroquinone 1, which we call strongylin A, was isolated from the marine sponge Strongylophora hartmani. Its structure was determined through spectroscopic methods, including 2D-13C homonuclear correlation spectroscopy (INADEQUATE). Both 1 and its acetate derivative are active in in vitro assays against the P-388 tumor cell line and influenza strain PR-8.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antiviral Agents* / chemistry
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Antiviral Agents* / isolation & purification
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Cell Line
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Orthomyxoviridae / drug effects
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Porifera*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
Substances
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Antineoplastic Agents
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Antiviral Agents
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Sesquiterpenes
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strongylin A