Abstract
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia rarely occur concurrently. We report a case in which these disorders were associated with an occult large granular lymphocyte leukemia. The peripheral blood cytopenias improved after glucocorticoids and intravenous immunoglobulin were administered, and response was maintained with cyclosporine. Large granular lymphocyte leukemia should be suspected in the setting of unexplained bone marrow failure.
Publication types
-
Case Reports
-
Research Support, N.I.H., Extramural
MeSH terms
-
Adult
-
Antigens, CD / analysis
-
Female
-
Humans
-
Leukemia, Large Granular Lymphocytic / complications*
-
Leukemia, Large Granular Lymphocytic / diagnosis
-
Leukemia, Large Granular Lymphocytic / drug therapy
-
Leukemia, Large Granular Lymphocytic / immunology
-
Purpura, Thrombocytopenic / complications*
-
Receptors, Immunologic / analysis
-
Red-Cell Aplasia, Pure / complications*
-
Signaling Lymphocytic Activation Molecule Family
Substances
-
Antigens, CD
-
CD244 protein, human
-
Receptors, Immunologic
-
Signaling Lymphocytic Activation Molecule Family