With the advancements that have been made in the field of minimally invasive surgery, combined laparoscopic procedures are now being performed for treating coexisting abdominal pathologies during the same surgery; this combined surgery thereby offers the maximum benefits to the patients. In this paper we describe how we perform laparoscopic splenectomy plus cholecystectomy at the same time to treat hereditary spherocytosis combined with cholelithiasis in two siblings.