Abstract
Eight d-ribo-phytosphingosine derivatives were synthesized from d-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects
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Apoptosis / physiology
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Combined Modality Therapy
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Drug Evaluation, Preclinical / methods
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Humans
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Jurkat Cells
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Leukemia, T-Cell / drug therapy
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Leukemia, T-Cell / pathology
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Leukemia, T-Cell / radiotherapy*
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Radiation-Sensitizing Agents / chemical synthesis*
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Radiation-Sensitizing Agents / therapeutic use
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Sphingosine / analogs & derivatives*
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Sphingosine / chemical synthesis
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Sphingosine / therapeutic use
Substances
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Radiation-Sensitizing Agents
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phytosphingosine
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Sphingosine