Abstract
BACKGROUND - To evaluate cerebrospinal fluid (CSF) markers for neuronal degeneration and demyelination in idiopathic normal pressure hydrocephalus (INPH), subcortical arteriosclerotic encephalopathy (SAE), and neurologically healthy subjects. METHODS - Lumbar CSF concentrations of sulfatide, neurofilament protein light (NFL), total-tau (T-tau), hyperphosphorylated tau (P-tau), and beta-amyloid(1-42) (Abeta42) were analyzed in 62 INPH patients, 26 SAE patients, and 23 neurologically healthy controls. In INPH patients, samples before and after shunt surgery were analysed. RESULTS - The CSF concentration of NFL was elevated in INPH and SAE compared with the controls, and levels of T-tau, P-tau, and Abeta42 were lower in INPH compared with SAE and controls. No difference was seen for sulfatide. All markers except Abeta42 were significantly elevated after shunt surgery. CONCLUSIONS - The most striking finding was the power of the combined pattern of NFL, P-tau, and Abeta42 in distinguishing between the clinical diagnoses of INPH, SAE, and neurologically healthy elderly.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Factors
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Aged
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Aged, 80 and over
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Amyloid beta-Peptides / analysis
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Amyloid beta-Peptides / cerebrospinal fluid
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Biomarkers / analysis
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Biomarkers / cerebrospinal fluid
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Cerebrospinal Fluid / chemistry*
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Cerebrospinal Fluid Pressure / physiology
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Cerebrospinal Fluid Shunts
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Diagnosis, Differential
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Female
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Humans
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Hydrocephalus, Normal Pressure / cerebrospinal fluid*
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Hydrocephalus, Normal Pressure / diagnosis*
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Hydrocephalus, Normal Pressure / physiopathology
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Intracranial Arteriosclerosis / cerebrospinal fluid
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Intracranial Arteriosclerosis / diagnosis
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Intracranial Arteriosclerosis / physiopathology
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Intracranial Hypertension / cerebrospinal fluid
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Intracranial Hypertension / diagnosis
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Intracranial Hypertension / physiopathology
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Male
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Middle Aged
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Nerve Degeneration / cerebrospinal fluid*
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Nerve Degeneration / diagnosis*
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Nerve Degeneration / etiology
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Neurofilament Proteins / analysis
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Neurofilament Proteins / cerebrospinal fluid
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Peptide Fragments / analysis
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Peptide Fragments / cerebrospinal fluid
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Predictive Value of Tests
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Sensitivity and Specificity
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Sulfoglycosphingolipids / analysis
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Sulfoglycosphingolipids / cerebrospinal fluid
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Up-Regulation / physiology
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tau Proteins / analysis
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tau Proteins / cerebrospinal fluid
Substances
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Amyloid beta-Peptides
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Biomarkers
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Neurofilament Proteins
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Peptide Fragments
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Sulfoglycosphingolipids
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amyloid beta-protein (1-42)
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neurofilament protein L
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tau Proteins