Abstract
Objective:
To evaluate the levels of bone morphogenetic protein-15 (BMP-15) in human follicular fluid (FF) and its association with response to ovarian stimulation.
Methods:
Western blotting was performed to determine the levels of BMP-15 in FF obtained from follicle aspirates in 70 patients undergoing IVF treatment. According to the response to ovarian stimulation the patients were divided into poor responder group and normal responder group.
Result:
BMP-15 levels in FF of poor responders were significantly higher than those in normal responders (1.01 +/- 0.34 vs 0.77 +/- 0.24, P<0.01).
Conclusion:
Increased levels of BMP-15 in FF may be associated with poor response to ovarian stimulation.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Blotting, Western
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Bone Morphogenetic Protein 15
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Female
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Follicle Stimulating Hormone / administration & dosage
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Follicular Fluid / drug effects
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Follicular Fluid / metabolism*
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Gonadotropin-Releasing Hormone / administration & dosage
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Gonadotropin-Releasing Hormone / analogs & derivatives
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Growth Differentiation Factor 9
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Humans
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Infertility, Female / metabolism*
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Intercellular Signaling Peptides and Proteins / biosynthesis*
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Ovary / drug effects
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Ovary / metabolism*
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Ovulation Induction
Substances
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BMP15 protein, human
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Bone Morphogenetic Protein 15
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GDF9 protein, human
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Growth Differentiation Factor 9
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Intercellular Signaling Peptides and Proteins
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Gonadotropin-Releasing Hormone
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LHRH, Ala(6)-Gly(10)-ethylamide-
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Follicle Stimulating Hormone