Abstract
We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identified by Western blot analysis of brain extracts.
MeSH terms
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Aged
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Alzheimer Disease / complications
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Alzheimer Disease / diagnostic imaging
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Alzheimer Disease / pathology*
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Amyloid beta-Peptides / metabolism
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Atrophy / pathology
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Blotting, Western
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Brain / diagnostic imaging
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Brain / pathology
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Brain Chemistry
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Creutzfeldt-Jakob Syndrome / complications
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Creutzfeldt-Jakob Syndrome / diagnostic imaging
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Creutzfeldt-Jakob Syndrome / pathology*
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Female
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Humans
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Immunoenzyme Techniques
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Tomography, X-Ray Computed